Postmarketing reports: Abnormal urine color (associated with hepatic failure), ImmunologicRare (0.01% to 0.1%): References1. "Multum Information Services, Inc. Expert Review Panel" 2. Cerner Multum, Inc. "Australian Product Information." O 03. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 04. Karma P, Pukander J, Penttila M, et al "The comparative efficacy and safety of clarithromycin and amoxycillin in the treatment of outpatients with acute maxillary sinusitis." J Antimicrob Chemother 27 (1991): 83-905. Pijpers E, Vanrijswijk REN, Takxkohlen B, Schrey G "A clarithromycin-induced myasthenic syndrome." Clin Infect Dis 22 (1996): 175-66. Zuckerman JM, Kaye KM "The newer macrolides: azithromycin and clarithromycin." Infect Dis Clin North Am 9 (1995): 731-457. Anderson G, Esmonde T, Coles S, et al "A comparative safety and efficacy study of clarithromycin and erythromycin stearate in community-acquired pneumonia." J Antimicrob Chemother 27 (1991): 117-248. Nightingale SD, Koster FT, Mertz GJ, Loss SD "Clarithromycin-induced mania in two patients with AIDS." Clin Infect Dis 20 (1995): 1563-49. Fong IW, Laforge J, Dubois J, Small D, Grossman R, Zakhari R, Thomas PT, Hoffstein V, Bourbeau J, Macdonald GF, Mclellan PA, "Clarithromycin versus cefaclor in lower respiratory tract infections." Clin Invest Med 18 (1995): 131-810. "Product Information. Biaxin (clarithromycin)." Abbott Pharmaceutical, Abbott Park, IL. 11. Wood M "The tolerance and toxicity of clarithromycin." J Hosp Infect 19 (1991): 39-4612. Hamedani P, Ali J, Hafeez S, et al "The safety and efficacy of clarithromycin in patients with legionella pneumonia." Chest 100 (1991): 1503-613. Straneo G, Scarpazza G "Efficacy and safety of clarithromycin versus josamycin in the treatment of hospitalized patients with bacterial pneumonia." J Int Med Res 18 (1990): 164-7014. Guay D, Craft J "Comparative safety and efficacy of clarithromycin and ampicillin in the treatment of out-patients with acute bacterial exacerbation of chronic bronchitis." J Intern Med 231 (1992): 295-30115. Hardy D, Guay D, Jones R "Clarithromycin, a unique macrolide." Diagn Microbiol Infect Dis 15 (1992): 39-5316. Macfarlane JT, Prewitt J, Gard P, Guion A "Comparison of amoxycillin and clarithromycin as initial treatment of community-acquired lower respiratory tract infections." Br J Gen Pract 46 (1996): 357-6017. Peters D, Clissold S "Clarithromycin: a review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential." Drugs 44 (1992): 117-6418. Dorrell L, Ellerton C, Cottrell DG, Snow MH "Toxicity of clarithromycin in the treatment of mycobacterium avium complex infection in a patient with AIDS." J Antimicrob Chemother 34 (1994): 605-619. Dautzenberg B, Piperno D, Diot P, Truffotpernot C, Chauvin JP "Clarithromycin in the treatment of mycobacterium avium lung infections in patients without AIDS." Chest 107 (1995): 1035-4020. Marchi E "Comparative efficacy and tolerability of clarithromycin and amoxycillin in the treatment of out-patients with acute maxillary sinusitis." Curr Med Res Opin 12 (1990): 19-2421. Liviu L, Yair L, Yehuda S "Pancreatitis induced by clarithromycin." Ann Intern Med 125 (1996): 70122. Fraschini F "Clinical efficacy and tolerance of two new macrolides, clarithromycin and josamycin, in the treatment of patients with acute exacerbations of chronic bronchitis." J Int Med Res 18 (1990): 171-7623. de Campora E, Camaioni A, Leonardi M, et al "Comparative efficacy and safety of roxithromycin and clarithromycin in upper respiratory tract infections." Diagn Microbiol Infect Dis 15 (1992): s119-2224. Shaheen N, Grimm IS "Fulminant hepatic failure associated with clarithromycin." Am J Gastroenterol 91 (1996): 394-525. Brown BA, Wallace RJ, Griffith DE, Girard W "Clarithromycin-induced hepatotoxicity." Clin Infect Dis 20 (1995): 1073-426. Liviu L, Yair L "Pancreatitis induced by clarithromycin." Ann Intern Med 125 (1996): 70127. Baylor P, Williams K "Interstitial nephritis, thrombocytopenia, hepatitis, and elevated serum amylase levels in a patient receiving clarithromycin therapy." Clin Infect Dis 29 (1999): 1350-128. Vangala R, Cernek PK "Hypersensitivity reaction to clarithromycin." Ann Pharmacother 30 (1996): 30029. Kundu S, Williams SR, Nordt SP, Clark RF "Clarithromycin-induced ventricular tachycardia." Ann Emerg Med 30 (1997): 542-430. Lee KL, Jim MH, Tang SC, Tai YT "QT prolongation and Torsades de pointes associated with clarithromycin." Am J Med 104 (1998): 395-631. Geiderman JM "Central nervous system disturbances following clarithromycin ingestion." Clin Infect Dis 29 (1999): 464-532. GomezGil E, Garcia F, Pintor L, Martinez JA, Mensa J, dePablo J "Clarithromycin-induced acute psychoses in peptic ulcer disease." Eur J Clin Microbiol Infect D 18 (1999): 70-133. Abouesh A, Hobbs WR "Clarithromycin-induced mania." Am J Psychiatry 155 (1998): 162634. Mermelstein HT "Clarithromycin-induced delirium in a general hospital." Psychosomatics 39 (1998): 540-235. Cone LA, Sneider RA, Nazemi R, Dietrich EJ "Mania due to clarithromycin therapy in a patient who was not infected with human immunodeficiency virus." Clin Infect Dis 22 (1996): 595-636. "WHO system finds 13 drugs with AEs not in PDR, Martindale." F-D-C Reports -- "The Pink Sheet" 60 (1998): 1637. Gavura SR, Nusinowitz S "Leukocytoclastic vasculitis associated with clarithromycin." Ann Pharmacother 32 (1998): 543-5Further informationAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.. Applies to clarithromycin: oral powder for reconstitution, oral tablet, oral tablet extended release General The most common side effects were abdominal pain /discomfort, diarrhea, nausea , vomiting, and dysgeusia/taste perversion.. Common side effects of Biaxin include: nausea, vomiting, upset stomach, diarrhea, unusual or unpleasant taste in your mouth, indigestion, abdominal pain,.