In rabbits, brimonidine tartrate at plasma levels higher than are achieved during therapy in humans, has been shown to cause increased preimplantation loss and postnatal growth reduction. Brimonidine eye drops should only be used during pregnancy if the potential benefit to the mother outweighs the potential risk to the foetus.. Alphagan ® (brimonidine tartrate) is an eye medication approved for the treatment of high eye pressure and open-angle glaucoma. Based on the results of animal studies, Alphagan appears to be relatively safe for use during pregnancy, although the full risks to humans are currently unknown.. Pregnancy category C. There are no adequate and well-controlled studies in pregnant women. Brinzolamide and Brimonidine Tartrate ophthalmic suspension should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.. Brimonidine should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus. Lactation : It is not known whether brimonidine is excreted in human milk; although in animal studies, brimonidine has been shown to be excreted in breast milk.. How to use Brimonidine TARTRATE Drops. To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.. Brimonidine tartrate ophthalmic solution should be used with caution in patients with depression, cerebral or coronary insufficiency, Raynaud’s phenomenon, orthostatic hypotension or thromboangiitis obliterans. During the studies there was a loss of effect in some patients. The IOP-lowering efficacy observed with brimonidine tartrate ophthalmic solution during the first month of therapy may .